How did eukaryotic organisms become so much more complex than prokaryotic ones, without a whole lot more genes? The answer lies in transcription factors. Experiments have shown that TFs can bind ...

If our genes are so similar, what really makes a eukaryote different from a prokaryote, or a human from E. coli? The answer lies in the difference in gene expression and regulation used.

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

Eukaryotic transcription initiation also requires the assembly of a pre-initiation complex involving RNA polymerase II and various transcription factors at the promoter. Once bound, RNA polymerase ...

Inositol phosphate metabolites produced by inositol metabolism enzymes serve as vital secondary messengers in eukaryotic ... in the transcription process governed by serum response factor (SRF ...