A doctor from the University of Palermo in Italy has published a case study of an adult cocaine user who experienced reduced withdrawal symptoms when given GLP-1 therapy. In the case study ...

This increases the body’s tolerance, requiring more frequent doses of cocaine and causing withdrawal symptoms, such as negative moods, when a person does not take it. In general, a cocaine heart ...

The reward circuit becomes accustomed to larger amounts of dopamine, reinforcing drug use as the individual needs more to feel the same high and avoid withdrawal. Cocaine also affects the body ...

The fact that ΔFosB accumulates following repeated cocaine exposure and persists during the withdrawal period supports the idea that this transcription factor and its downstream target ...

These data were analyzed independently and in relation to our previously reported data involving human cocaine abusers, in order to determine which expression changes were drug specific and which ...